Antibiotics
When nasal steroids do not take away your sinus pain, antibiotics may help. The bacteria that infect your sinuses are similar to those that infect your lungs. CF patients get sinus infections a lot, and antibiotic treatments may take several weeks to stop them.

Irrigation
Flushing out your sinuses with a saline solution, a process called irrigation, may reduce the amount of mucus and bacteria in your sinuses. Because these sinuses are difficult to reach, antibiotics you take by mouth or through an IV rarely get rid of all the bacteria.

Sinus Surgery
When medications do not heal your sinus infection, you may have to have an operation to drain the sinuses and remove the infection. Sometimes patients develop polyps in their sinuses. Shaped like little fingers of skin, polyps can interfere with breathing, and cause pain or an infection. Unfortunately, nasal polyps often grow back even after they are removed.