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Science of CF: Gastrointestinal Tract Problems
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Over 90 percent of people with CF have an impaired pancreas leading to the inability to produce enzymes that help to digest food. Some people with CF have a working pancreas that can produce enzymes. Normally, food proteins are digested by stomach acid and enter the small intestine where pancreatic and gall bladder secretions are added.

 Pancreatic enzymes

Types of Secretions:
(1) Bicarbonate is a non-acidic solution to neutralize the stomach acid.
(2) Pancreatic digestive enzymes aiding in absorption of fats, sugars and proteins from the gut. These work best in a non-acidic environment and may become inactive in acidic environments.
(3) Bile, produced in the liver and stored in the gall bladder, helps with fat digestion and eliminates waste products.

Select from the menu above to view an animation on how digestion occurs in the stomach or in the duodenum.

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