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Basic Science

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Physician at microscope

The basic science research of CF explores the Cystic Fibrosis transmembrane conductance regulator (CFTR) gene, which codes for a chloride channel on the surface of specialized cells and a protein by the same name. Over 1000 mutations in the CFTR gene have been found that can lead to CF. Understanding how mutations in the CFTR gene translate into the symptoms of CF is the goal of basic science researchers at Hopkins. New functions of the CFTR protein are regularly discovered as Hopkins scientists continue to probe its properties in search of better targets for drug and gene therapies.